HMM Summary Page: TIGR00425

Functionputative rRNA pseudouridine synthase
Trusted Cutoff238.15
Domain Trusted Cutoff238.15
Noise Cutoff169.60
Domain Noise Cutoff169.60
Isology Typehypoth_equivalog
EC Number5.4.99.-
HMM Length322
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedDec 19 2011 11:27AM
CommentThis family, found in archaea and eukaryotes, includes the only archaeal proteins markedly similar to bacterial TruB, the tRNA pseudouridine 55 synthase. However, among two related yeast proteins, the archaeal set matches yeast YLR175w far better than YNL292w. The first, termed centromere/microtubule binding protein 5 (CBF5), is an apparent rRNA pseudouridine synthase, while the second is the exclusive tRNA pseudouridine 55 synthase for both cytosolic and mitochondrial compartments. It is unclear whether archaeal proteins found by this model modify tRNA, rRNA, or both.
ReferencesSE TIGR GA hmmls DR HAMAP; MF_01081; 17 of 26