HMM Summary Page: TIGR00424

Function5'-adenylylsulfate reductase, thioredoxin-independent
Trusted Cutoff553.20
Domain Trusted Cutoff553.20
Noise Cutoff347.35
Domain Noise Cutoff347.35
Isology Typeequivalog
HMM Length464
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0006790: sulfur compound metabolic process biological_process
GO:0016667: oxidoreductase activity, acting on a sulfur group of donors molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, involved in the assimilation of inorganic sulfate, is closely related to the thioredoxin-dependent PAPS reductase of Bacteria (CysH) and Saccharomyces cerevisiae. However, it has its own C-terminal thioredoxin-like domain and is not thioredoxin-dependent. Also, it has a substrate preference for 5'-adenylylsulfate (APS) over 3'-phosphoadenylylsulfate (PAPS) so the pathway does not require an APS kinase (CysC) to convert APS to PAPS. Arabidopsis thaliana appears to have three isozymes, all able to complement E. coli CysH mutants (even in backgrounds lacking thioredoxin or APS kinase) but likely localized to different compartments in Arabidopsis.
ReferencesRM 97075174 SE TIGR GA hmmls