HMM Summary Page: TIGR00421

Functionpolyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
Trusted Cutoff108.90
Domain Trusted Cutoff108.90
Noise Cutoff69.30
Domain Noise Cutoff69.30
Isology Typesubfamily
EC Number4.1.1.-
HMM Length181
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0006725: cellular aromatic compound metabolic process biological_process
GO:0016831: carboxy-lyase activity molecular_function
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn E.coli, the protein UbiX (3-octaprenyl-4-hydroxybenzoate carboxy-lyase) has been shown to be involved in the third step of ubiquinone biosynthesis. It catalyzes the reaction [3-octaprenyl-4-hydroxybenzoate = 2-octaprenylphenol + CO2]. The knockout of the homologous protein in yeast confers sensitivity to phenylacrylic acid. Members are not restricted to ubiquinone-synthesizing species. This family represents a distinct clade within the flavoprotein family of Pfam model PF02441.
ReferencesDR Swissprot; P33751; DR Swissprot; P09550; SE TIGR GA hmmls DR PFAM; PF02441 DR InterPro; IPR003382
Genome PropertyGenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)