HMM Summary Page: TIGR00420

FunctiontRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Gene SymboltrmU
Trusted Cutoff236.95
Domain Trusted Cutoff236.95
Noise Cutoff185.85
Domain Noise Cutoff185.85
Isology Typeequivalog
EC Number2.1.1.61
HMM Length351
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0004808: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006396: RNA processing biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommenttRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (trmU, asuE, or mnmA) is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine (mnm5s2U34) present in the wobble position of some tRNAs. This enzyme appears not to occur in the Archaea.
ReferencesDR Swissprot; P25745 RM 87250459; DR ECOCYC; EG11344; SE TIGR GA hmmls DR HAMAP; MF_00144; 594 of 628
Genome PropertyGenProp0704: tRNA U34 carboxymethylaminomethyl modification (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)