HMM Summary Page: TIGR00419

Functiontriose-phosphate isomerase
Gene SymboltpiA
Trusted Cutoff130.60
Domain Trusted Cutoff130.60
Noise Cutoff113.50
Domain Noise Cutoff113.50
Isology Typeequivalog
EC Number5.3.1.1
HMM Length228
Mainrole CategoryEnergy metabolism
Subrole CategoryGlycolysis/gluconeogenesis
Gene Ontology TermGO:0004807: triose-phosphate isomerase activity molecular_function
GO:0006096: glycolysis biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentTriosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family.
ReferencesDR ECOCYC; EG11015; DR PROSITE; PDOC00155; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00147; 450 of 469
Genome PropertyGenProp0120: pentose phosphate cycle (HMM)
GenProp0691: glycolysis (HMM)