HMM Summary Page: TIGR00412

Functionredox-active disulfide protein 2
Trusted Cutoff73.50
Domain Trusted Cutoff73.50
Noise Cutoff55.60
Domain Noise Cutoff55.60
Isology Typehypoth_equivalog
HMM Length78
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis small protein is found in three archaeal species so far (Methanococcus jannaschii, Archeoglobus fulgidus, and Methanobacterium thermoautotrophicum) as well as in Anabaena PCC7120. It is homologous to thioredoxins, glutaredoxins, and protein disulfide isomerases, and shares with them a redox-active disulfide. The redox active disulfide region CXXC motif resembles neither thioredoxin nor glutaredoxin. A closely related protein found in the same three Archaea, described by redox_disulf_1, has a glutaredoxin-like CP[YH]C sequence; it has been characterized in functional assays as redox-active but unlikely to be a thioredoxin or glutaredoxin.
ReferencesA2 hmmalign SE TIGR GA hmmls BD /build_dir/0478