HMM Summary Page: TIGR00409

Functionproline--tRNA ligase
Gene SymbolproS
Trusted Cutoff306.70
Domain Trusted Cutoff306.70
Noise Cutoff253.65
Domain Noise Cutoff253.65
Isology Typeequivalog
EC Number6.1.1.15
HMM Length568
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004827: proline-tRNA ligase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006433: prolyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentProlyl-tRNA synthetase is a class II tRNA synthetase and is recognized by pfam HMM tRNA-synt_2b, which recognizes tRNA synthetases for Gly, His, Ser, and Pro. The prolyl-tRNA synthetases are divided into two widely divergent groups. This group includes enzymes from Escherichia coli, Bacillus subtilis, Aquifex aeolicus, the spirochete Treponema pallidum, Synechocystis PCC6803, and one of the two prolyL-tRNA synthetases of Saccharomyces cerevisiae. The other group includes the Pro-specific domain of a human multifunctional tRNA ligase and the prolyl-tRNA synthetases from the Archaea, the Mycoplasmas, and the spirochete Borrelia burgdorferi.
ReferencesSE TIGR GA hmmls AL clustalw, seaview, belvu DR HAMAP; MF_01570; 69 of 70
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)