HMM Summary Page: TIGR00408

Functionproline--tRNA ligase
Gene SymbolproS
Trusted Cutoff437.00
Domain Trusted Cutoff437.00
Noise Cutoff251.35
Domain Noise Cutoff251.35
Isology Typeequivalog
EC Number6.1.1.15
HMM Length475
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004827: proline-tRNA ligase activity molecular_function
GO:0006433: prolyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentProlyl-tRNA synthetase is a class II tRNA synthetase and is recognized by pfam HMM tRNA-synt_2b, which recognizes tRNA synthetases for Gly, His, Ser, and Pro. The prolyl-tRNA synthetases are divided into two widely divergent families. This family includes the archaeal enzyme, the Pro-specific domain of a human multifunctional tRNA ligase, and the enzyme from the spirochete Borrelia burgdorferi. The other family includes enzymes from Escherichia coli, Bacillus subtilis, Synechocystis PCC6803, and one of the two prolyL-tRNA synthetases of Saccharomyces cerevisiae.
ReferencesSE TIGR GA hmmls DR HAMAP; MF_01571; 112 of 114
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)
GenProp0831: archaeal core gene set, exactly 1 per genome (HMM)