HMM Summary Page: TIGR00405

Functiontranscription elongation factor Spt5
Trusted Cutoff69.95
Domain Trusted Cutoff69.95
Noise Cutoff49.85
Domain Noise Cutoff49.85
Isology Typeequivalog
HMM Length145
Mainrole CategoryProtein synthesis
Subrole CategoryRibosomal proteins: synthesis and modification
Gene Ontology TermGO:0003735: structural constituent of ribosome molecular_function
GO:0006412: translation biological_process
GO:0022625: cytosolic large ribosomal subunit cellular_component
AuthorHaft DH, Loftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedSep 16 2014 4:02PM
CommentThis protein contains a KOW domain, shared by bacterial NusG and the uL24 (previously L24p/L26e) family of ribosomal proteins. The most recent papers and crystal structures make this a transcription elongation factor rather than a ribosomal protein.
ReferencesDR PFAM; PF00467; RN [1] RM PMID:20197319 RT Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. RA Hirtreiter A, Damsma GE, Cheung AC, Klose D, Grohmann D, Vojnic E, Martin AC, Cramer P, Werner F RL Nucleic Acids Res. 2010 Jul;38(12):4040-51.
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)