HMM Summary Page: TIGR00401

Functionpeptide-methionine (S)-S-oxide reductase
Gene SymbolmsrA
Trusted Cutoff108.10
Domain Trusted Cutoff108.10
Noise Cutoff71.15
Domain Noise Cutoff71.15
Isology Typeequivalog_domain
EC Number1.8.4.11
HMM Length153
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0000317: methionine-S-oxide reductase activity molecular_function
GO:0006979: response to oxidative stress biological_process
GO:0008113: peptide-methionine-(S)-S-oxide reductase activity molecular_function
GO:0030091: protein repair biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens.
ReferencesRN [1] RT The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi. RA Hassouni ME, Chambost JP, Expert D, Van Gijsegem F, Barras F RL Proc Natl Acad Sci U S A 1999 Feb 2;96(3):887-92 RN [2] RM 96353931 RT Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. RA Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR RL Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7985-90 DR Swissprot; P27110; DR ECOCYC; EG11433 msrA; SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_01401; 194 of 197
Genome PropertyGenProp0182: reduction of oxidized methionine (HMM)
GenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM)