| Accession | TIGR00384 |
| Name | dhsB |
| Function | succinate dehydrogenase and fumarate reductase iron-sulfur protein |
| Trusted Cutoff | 88.00 |
| Domain Trusted Cutoff | 88.00 |
| Noise Cutoff | 78.25 |
| Domain Noise Cutoff | 78.25 |
| Isology Type | subfamily |
| HMM Length | 222 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Aerobic |
| Gene Ontology Term | GO:0000104: succinate dehydrogenase activity molecular_function |
| | GO:0006099: tricarboxylic acid cycle biological_process |
| | GO:0009060: aerobic respiration biological_process |
| | GO:0009061: anaerobic respiration biological_process |
| Author | Loftus BJ, Haft DH |
| Entry Date | Apr 20 1999 2:07PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Succinate dehydrogenase and fumarate reductase are reverse directions of the same enzymatic interconversion, succinate + FAD+ = fumarate + FADH2 (EC 1.3.11.1). In E. coli, the forward and reverse reactions are catalyzed by distinct complexes: fumarate reductase operates under anaerobic conditions and succinate dehydrogenase operates under aerobic conditions. This model also describes a region of the B subunit of a cytosolic archaeal fumarate reductase. |
| References | A2 hmmalign
RM 98237600;
RT Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
RA Heim S, Kunkel A, Thauer RK, Hedderich R
RL Eur J Biochem 1998 Apr 1;253(1):292-9
DR SWISSPROT; P07014;
DR SWISSPROT; P44893;
DR EGAD; 20011;
DR PROSITE; PS00198; 4FE4S_FERREDOXIN;
DR PFAM; PF00037; fer4;
SE TIGR
GA hmmls
AL clustalw, belvu
BD 0501 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
| | GenProp0756: fumarate reductase complex (HMM) |
