HMM Summary Page: TIGR00379

Functioncobyrinic acid a,c-diamide synthase
Gene SymbolcobB
Trusted Cutoff261.40
Domain Trusted Cutoff261.40
Noise Cutoff152.40
Domain Noise Cutoff152.40
Isology Typeequivalog
EC Number6.3.1.-
HMM Length449
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0009236: cobalamin biosynthetic process biological_process
GO:0042242: cobyrinic acid a,c-diamide synthase activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes cobyrinic acid a,c-diamide synthase, the cobB (cbiA in Salmonella) protein of cobalamin biosynthesis. It is responsible for the amidation of carboxylic groups at positions A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP hydrogenolyzed for each amidation.
ReferencesDR SWISSPROT; P21632; SE TIGR GA hmmls DR HAMAP; MF_00027; 53 of 53
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)
GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM)