HMM Summary Page: TIGR00377

Functionanti-anti-sigma factor
Trusted Cutoff53.45
Domain Trusted Cutoff53.45
Noise Cutoff27.20
Domain Noise Cutoff27.20
Isology Typesuperfamily
HMM Length108
Mainrole CategoryRegulatory functions
Subrole CategoryProtein interactions
Gene Ontology TermGO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0045152: antisigma factor binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins, but score below the trusted cutoff currently set for this superfamily HMM.
ReferencesA2 hmmalign SE TIGR GA hmmls AL clustalw, hmma, belvu BD /build_dir/0468