HMM Summary Page: TIGR00372

FunctionCRISPR-associated protein Cas4
Gene Symbolcas4
Trusted Cutoff65.00
Domain Trusted Cutoff65.00
Noise Cutoff59.90
Domain Noise Cutoff59.90
Isology Typeequivalog
HMM Length180
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH, Loftus BJ
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.
ReferencesDR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM 11952905 RT Identification of genes that are associated with DNA repeats in prokaryotes. RA Jansen R, Embden JD, Gaastra W, Schouls LM. RL Mol Microbiol 2002 Mar;43(6):1565-75 RN [3] RM 11788711 RT A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. RA Makarova KS, Aravind L, Grishin NV, Rogozin IB, Koonin EV. RL Nucleic Acids Res. 2002 Jan 15;30(2):482-96.
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0313: CRISPR system, I-C/Dvulg subtype (HMM-CLUST)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)
GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST)
GenProp0469: CRISPR system, Dpsyc subtype (HMM-CLUST)
GenProp0768: CRISPR system, Pging subtype (HMM-CLUST)
GenProp0922: CRISPR system, Myxan subtype (HMM-CLUST)