HMM Summary Page: TIGR00365

Functionmonothiol glutaredoxin, Grx4 family
Gene SymbolgrxD
Trusted Cutoff117.10
Domain Trusted Cutoff117.10
Noise Cutoff85.70
Domain Noise Cutoff85.70
Isology Typeequivalog
HMM Length99
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0009055: electron carrier activity molecular_function
GO:0030508: thiol-disulfide exchange intermediate activity molecular_function
AuthorHaft DH, Loftus BJ
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe gene for the member of this glutaredoxin family in E. coli, originally designated ydhD, is now designated grxD. Its protein, Grx4, is a monothiol glutaredoxin similar to Grx5 of yeast, which is involved in iron-sulfur cluster formation.
ReferencesRN [1] RM PMID:15833738 RT A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase. RA Fernandes AP, Fladvad M, Berndt C, Andresen C, Lillig CH, Neubauer P, Sunnerhagen M, Holmgren A, Vlamis-Gardikas A RL J Biol Chem. 2005 Jul 1;280(26):24544-52.