| Accession | TIGR00357 |
| Name | TIGR00357 |
| Function | methionine-R-sulfoxide reductase |
| Gene Symbol | msrB |
| Trusted Cutoff | 113.05 |
| Domain Trusted Cutoff | 113.05 |
| Noise Cutoff | 84.20 |
| Domain Noise Cutoff | 84.20 |
| Isology Type | equivalog_domain |
| EC Number | 1.8.4.- |
| HMM Length | 134 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein modification and repair |
| Gene Ontology Term | GO:0000318: protein-methionine-R-oxide reductase activity molecular_function |
| | GO:0006979: response to oxidative stress biological_process |
| | GO:0030091: protein repair biological_process |
| Author | Loftus BJ, Sullivan SA, Haft DH |
| Entry Date | Apr 20 1999 2:05PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes a domain found in PilB, a protein important for pilin expression, N-terminal to a domain coextensive to with the known peptide methionine sulfoxide reductase (MsrA), a protein repair enzyme, of E. coli. Among the early completed genomes, this module is found if and only if MsrA is also found, whether N-terminal to MsrA (as for Helicobacter pylori), C-terminal (as for Treponema pallidum), or in a separate polypeptide. Although the function of this region is not clear, an auxiliary function to MsrA is suggested. |
| References | RM 96353931
RT Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.
RA Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR
RL Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7985-90
RM 99128332
DR SP:P14930, SP:P45213
SE TIGR
GA hmmls
AL clustalw, belvu
DR HAMAP; MF_01400; 117 of 118 |
| Genome Property | GenProp0182: reduction of oxidized methionine (HMM) |
| | GenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM) |
