HMM Summary Page: TIGR00357

Functionmethionine-R-sulfoxide reductase
Gene SymbolmsrB
Trusted Cutoff113.05
Domain Trusted Cutoff113.05
Noise Cutoff84.20
Domain Noise Cutoff84.20
Isology Typeequivalog_domain
EC Number1.8.4.-
HMM Length134
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0000318: protein-methionine-R-oxide reductase activity molecular_function
GO:0006979: response to oxidative stress biological_process
GO:0030091: protein repair biological_process
AuthorLoftus BJ, Sullivan SA, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a domain found in PilB, a protein important for pilin expression, N-terminal to a domain coextensive to with the known peptide methionine sulfoxide reductase (MsrA), a protein repair enzyme, of E. coli. Among the early completed genomes, this module is found if and only if MsrA is also found, whether N-terminal to MsrA (as for Helicobacter pylori), C-terminal (as for Treponema pallidum), or in a separate polypeptide. Although the function of this region is not clear, an auxiliary function to MsrA is suggested.
ReferencesRM 96353931 RT Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens. RA Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR RL Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7985-90 RM 99128332 DR SP:P14930, SP:P45213 SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_01400; 117 of 118
Genome PropertyGenProp0182: reduction of oxidized methionine (HMM)
GenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM)