HMM Summary Page: TIGR00354

FunctionDNA polymerase II, large subunit DP2
Gene SymbolpolC
Trusted Cutoff702.15
Domain Trusted Cutoff702.15
Noise Cutoff544.30
Domain Noise Cutoff544.30
Isology Typeequivalog
EC Number2.7.7.7
HMM Length1096
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003887: DNA-directed DNA polymerase activity molecular_function
GO:0004527: exonuclease activity molecular_function
GO:0006260: DNA replication biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the large subunit, DP2, of a two subunit novel Archaeal replicative DNA polymerase first characterized for Pyrococcus furiosus. Structure of DP2 appears to be organized as a ~950 residue component separated from a ~300 residue component by a ~150 residue intein. The other subunit, DP1, has sequence similarity to the eukaryotic DNA polymerase delta small subunit.
ReferencesRN [1] RM 98006263 RT A novel DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus: gene cloning, expression, and characterization. RA Uemori T, Sato Y, Kato I, Doi H, Ishino Y RL Genes Cells 1997 Aug;2(8):499-512 RN [2] RM 99045670 RT A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase. RA Cann IK, Komori K, Toh H, Kanai S, Ishino Y RL Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14250-5 SE TIGR GA hmmls DR HAMAP; MF_00324; 30 of 30