| Accession | TIGR00354 |
| Name | polC |
| Function | DNA polymerase II, large subunit DP2 |
| Gene Symbol | polC |
| Trusted Cutoff | 702.15 |
| Domain Trusted Cutoff | 702.15 |
| Noise Cutoff | 544.30 |
| Domain Noise Cutoff | 544.30 |
| Isology Type | equivalog |
| EC Number | 2.7.7.7 |
| HMM Length | 1096 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0003887: DNA-directed DNA polymerase activity molecular_function |
| | GO:0004527: exonuclease activity molecular_function |
| | GO:0006260: DNA replication biological_process |
| Author | Loftus BJ, Haft DH |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the large subunit, DP2, of a two subunit novel Archaeal replicative DNA polymerase first characterized for Pyrococcus furiosus. Structure of DP2 appears to be organized as a ~950 residue component separated from a ~300 residue component by a ~150 residue intein. The other subunit, DP1, has sequence similarity to the eukaryotic DNA polymerase delta small subunit. |
| References | RN [1]
RM 98006263
RT A novel DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus: gene cloning, expression, and characterization.
RA Uemori T, Sato Y, Kato I, Doi H, Ishino Y
RL Genes Cells 1997 Aug;2(8):499-512
RN [2]
RM 99045670
RT A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase.
RA Cann IK, Komori K, Toh H, Kanai S, Ishino Y
RL Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14250-5
SE TIGR
GA hmmls
DR HAMAP; MF_00324; 30 of 30 |
