HMM Summary Page: TIGR00350

Functioncell envelope-related function transcriptional attenuator common domain
Trusted Cutoff62.30
Domain Trusted Cutoff62.30
Noise Cutoff49.25
Domain Noise Cutoff49.25
Isology Typedomain
HMM Length152
Mainrole CategoryRegulatory functions
Subrole CategoryOther
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane-bound proteins. One of these is proteins psr, described as a penicillin binding protein 5 (PDP-5) synthesis repressor. Another is Bacillus subtilis LytR, described as a transcriptional attenuator of itself and the LytABC operon, where LytC is N-acetylmuramoyl-L-alanine amidase. A third is CpsA, a putative regulatory protein involved in exocellular polysaccharide biosynthesis. Besides the region of strong similarily represented by this HMM, these proteins share the property of having a short putative N-terminal cytoplasmic domain and transmembrane domain forming a signal-anchor.
ReferencesRM 97149274 RT The cpsABCDE genes involved in polysaccharide production in Streptococcus salivarius ssp. thermophilus strain NCBF 2393. RA Griffin AM, Morris VJ, Gasson MJ RL Gene 1996 Dec 12;183(1-2):23-7 SE TIGR GA hmmls DR HAMAP; MF_01140; 8 of 8