HMM Summary Page: TIGR00348

Functiontype I site-specific deoxyribonuclease, HsdR family
Gene SymbolhsdR
Trusted Cutoff284.55
Domain Trusted Cutoff284.55
Noise Cutoff213.45
Domain Noise Cutoff213.45
Isology Typesubfamily
EC Number3.1.21.3
HMM Length674
Mainrole CategoryDNA metabolism
Subrole CategoryRestriction/modification
Gene Ontology TermGO:0009035: Type I site-specific deoxyribonuclease activity molecular_function
GO:0009307: DNA restriction-modification system biological_process
GO:0019812: Type I site-specific deoxyribonuclease complex cellular_component
AuthorLoftus BJ
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis gene is part of the type I restriction and modification system which is composed of three polypeptides R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognize specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They also catalyse the reactions of EC and EC, with similar site specificity.(J. Mol. Biol. 271 (3), 342-348 (1997)). Members of this family are assumed to differ from each other in DNA site specificity.
ReferencesA2 hmmalign DR EGAD:10320, SE TIGR GA hmmls