HMM Summary Page: TIGR00347

Functiondethiobiotin synthase
Gene SymbolbioD
Trusted Cutoff83.30
Domain Trusted Cutoff83.30
Noise Cutoff56.05
Domain Noise Cutoff56.05
Isology Typeequivalog
EC Number6.3.3.3
HMM Length166
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryBiotin
Gene Ontology TermGO:0004141: dethiobiotin synthase activity molecular_function
GO:0009102: biotin biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentDethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor.
ReferencesDR SWISSPROT; P13000; DR ECOCYC; EG10120; bioD; RM 97270412 RT Active site mutants of Escherichia coli dethiobiotin synthetase: effects of mutations on enzyme catalytic and structural properties. RA Yang G, Sandalova T, Lohman K, Lindqvist Y, Rendina AR RL Biochemistry 1997 Apr 22;36(16):4751-60 SE TIGR GA hmmls DR HAMAP; MF_00336; 181 of 183
Genome PropertyGenProp0036: biotin biosynthesis (HMM)