HMM Summary Page: TIGR00345

Functiontransport-energizing ATPase, TRC40/GET3/ArsA family
Trusted Cutoff135.00
Domain Trusted Cutoff135.00
Noise Cutoff120.00
Domain Noise Cutoff120.00
Isology Typesubfamily
EC Number3.6.1.-
HMM Length299
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedMar 7 2012 9:41AM
CommentMembers of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see PF02040) for As(III) efflux.
ReferencesRN [1] RM PMID:20981284 RT Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. RA Castillo R, Saier MH RL Int J Microbiol. 2010;2010:187373. RN [2] RM PMID:22124326 RT Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue. RA Suloway CJ, Rome ME, Clemons WM Jr RL EMBO J. 2011 Nov 29;31(3):707-19. RN [3] RM PMID:8674982 RT The arsenical resistance operon of IncN plasmid R46. RA Bruhn DF, Li J, Silver S, Roberto F, Rosen BP RL FEMS Microbiol Lett. 1996 Jun 1;139(2-3):149-53.