HMM Summary Page: TIGR00345
| Accession | TIGR00345 |
| Name | GET3_arsA_TRC40 |
| Function | transport-energizing ATPase, TRC40/GET3/ArsA family |
| Trusted Cutoff | 135.00 |
| Domain Trusted Cutoff | 135.00 |
| Noise Cutoff | 120.00 |
| Domain Noise Cutoff | 120.00 |
| Isology Type | subfamily |
| EC Number | 3.6.1.- |
| HMM Length | 299 |
| Mainrole Category | Hypothetical proteins |
| Subrole Category | Conserved |
| Author | Loftus BJ, Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Mar 7 2012 9:41AM |
| Comment | Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see PF02040) for As(III) efflux. |
| References | RN [1] RM PMID:20981284 RT Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. RA Castillo R, Saier MH RL Int J Microbiol. 2010;2010:187373. RN [2] RM PMID:22124326 RT Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue. RA Suloway CJ, Rome ME, Clemons WM Jr RL EMBO J. 2011 Nov 29;31(3):707-19. RN [3] RM PMID:8674982 RT The arsenical resistance operon of IncN plasmid R46. RA Bruhn DF, Li J, Silver S, Roberto F, Rosen BP RL FEMS Microbiol Lett. 1996 Jun 1;139(2-3):149-53. |