HMM Summary Page: TIGR00339

Functionsulfate adenylyltransferase
Gene Symbolsat
Trusted Cutoff322.95
Domain Trusted Cutoff322.95
Noise Cutoff181.80
Domain Noise Cutoff181.80
Isology Typeequivalog_domain
EC Number2.7.7.4
HMM Length383
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0004781: sulfate adenylyltransferase (ATP) activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme forms adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, the first step in the formation of the activated sulfate donor 3'-phosphoadenylylsulfate (PAPS). In some cases, it is found in a bifunctional protein in which the other domain, APS kinase, catalyzes the second and final step, the phosphorylation of APS to PAPS; the combined ATP sulfurylase/APS kinase may be called PAPS synthase. Members of this family also include the dissimilatory sulfate adenylyltransferase (sat) of the sulfate reducer Archaeoglobus fulgidus.
ReferencesRM 96094345 RT The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. RA Li H, Deyrup A, Mensch JR Jr, Domowicz M, Konstantinidis AK, Schwartz NB RL J Biol Chem 1995 Dec 8;270(49):29453-9 SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00066; 58 of 59
Genome PropertyGenProp0149: sulfate reduction to sulfide, assimilatory (HMM)
GenProp0149: sulfate reduction to sulfide, assimilatory (HMM)
GenProp0155: dissimilatory sulfate reduction (HMM)