HMM Summary Page: TIGR00337

FunctionCTP synthase
Gene SymbolpyrG
Trusted Cutoff462.75
Domain Trusted Cutoff462.75
Noise Cutoff289.55
Domain Noise Cutoff289.55
Isology Typeequivalog
EC Number6.3.4.2
HMM Length526
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPyrimidine ribonucleotide biosynthesis
Gene Ontology TermGO:0003883: CTP synthase activity molecular_function
GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentCTP synthase is involved in pyrimidine ribonucleotide/ribonucleoside metabolism. The enzyme catalyzes the reaction L-glutamine + H2O + UTP + ATP = CTP + phosphate + ADP + L-glutamate. The enzyme exists as a dimer of identical chains that aggregates as a tetramer. This gene has been found circa 500 bp 5' upstream of enolase in both beta (Nitrosomonas europaea) and gamma (E.coli) subdivisions of proteobacterium (FEMS Microbiol Lett 1998 Aug 1;165(1):153-7).
ReferencesDR ECOCYC; EG10810; pyrG; DR PROSITE; PDOC00405; SE TIGR GA hmmls DR HAMAP; MF_01227; 345 of 347
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)