HMM Summary Page: TIGR00336

Functionorotate phosphoribosyltransferase
Gene SymbolpyrE
Trusted Cutoff106.80
Domain Trusted Cutoff106.80
Noise Cutoff69.65
Domain Noise Cutoff69.65
Isology Typeequivalog_domain
EC Number2.4.2.10
HMM Length173
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPyrimidine ribonucleotide biosynthesis
Gene Ontology TermGO:0004588: orotate phosphoribosyltransferase activity molecular_function
GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentOrotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC The combined activity of EC and EC is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme.
ReferencesDR PROSITE; PDOC00096; DR ECOCYC; EG10808; pyrE; SE TIGR GA hmmls DR HAMAP; MF_01208; 248 of 300
Genome PropertyGenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)