| Accession | TIGR00336 |
| Name | pyrE |
| Function | orotate phosphoribosyltransferase |
| Gene Symbol | pyrE |
| Trusted Cutoff | 106.80 |
| Domain Trusted Cutoff | 106.80 |
| Noise Cutoff | 69.65 |
| Domain Noise Cutoff | 69.65 |
| Isology Type | equivalog_domain |
| EC Number | 2.4.2.10 |
| HMM Length | 173 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | Pyrimidine ribonucleotide biosynthesis |
| Gene Ontology Term | GO:0004588: orotate phosphoribosyltransferase activity molecular_function |
| | GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process |
| Author | Loftus BJ |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+.
In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase.
The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. |
| References | DR PROSITE; PDOC00096;
DR ECOCYC; EG10808; pyrE;
SE TIGR
GA hmmls
DR HAMAP; MF_01208; 248 of 300 |
| Genome Property | GenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM) |
