HMM Summary Page: TIGR00334

Functionribonuclease M5
Gene SymbolrnmV
Trusted Cutoff110.65
Domain Trusted Cutoff110.65
Noise Cutoff61.85
Domain Noise Cutoff61.85
Isology Typeequivalog
EC Number3.1.26.8
HMM Length174
Mainrole CategoryTranscription
Subrole CategoryRNA processing
Gene Ontology TermGO:0006364: rRNA processing biological_process
GO:0043822: ribonuclease M5 activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of orthologous proteins shows a weak but significant similarity to the central region of the DnaG-type DNA primase. The region of similarity is termed the Toprim (topoisomerase-primase) domain and is also shared by RecR, OLD family nucleases, and type IA and II topoisomerases.
ReferencesRN [1] RM PMID:16077031 RT The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member. RA Allemand F, Mathy N, Brechemier-Baey D, Condon C RL Nucleic Acids Res. 2005 Aug 2;33(13):4368-76 RN [2] RM 98391745 RT Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. RA Aravind L, Leipe DD, Koonin EV RL Nucleic Acids Res 1998 Sep 15;26(18):4205-13 SE TIGR GA hmmls