HMM Summary Page: TIGR00325

FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Gene SymbollpxC
Trusted Cutoff187.25
Domain Trusted Cutoff187.25
Noise Cutoff155.00
Domain Noise Cutoff155.00
Isology Typeequivalog
EC Number3.5.1.-
HMM Length297
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008759: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity molecular_function
GO:0009245: lipid A biosynthetic process biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentUDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase from E. coli , LpxC, was previously designated EnvA. This enzyme is involved in lipid-A precursor biosynthesis. It is essential for cell viability.
ReferencesSE TIGR AL clustalw DR ECOCYC; EG10265; lpxC DR SWISSPROT; P07652 GA hmmls RN [1] RM 99152380 RT UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. RA Jackman JE, Raetz CR, Fierke CA RL Biochemistry 1999 Feb 9;38(6):1902-11 DR HAMAP; MF_00388; 197 of 201
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)