HMM Summary Page: TIGR00321

Functiondeoxyhypusine synthase
Trusted Cutoff304.25
Domain Trusted Cutoff304.25
Noise Cutoff79.75
Domain Noise Cutoff79.75
Isology Typeequivalog
EC Number2.5.1.46
HMM Length301
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0008612: peptidyl-lysine modification to hypusine biological_process
GO:0050983: deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentDeoxyhypusine synthase is responsible for the first step in creating hypusine. Hypusine is a modified amino acid found in eukaryotes and in archaea in their respective forms of initiation factor 5A. Its presence is confirmed in archaeal genera Pyrococcus (PMID:12761201), Sulfolobus, Halobacterium, and Haloferax (PMID:10648545), but in an older report was not detected in Methanococcus voltae (J Biol Chem 1987 Dec 5;262(34):16585-9). This family of apparent orthologs has an unusual UPGMA difference tree, in which the members from the archaea M. jannaschii and P. horikoshii cluster with the known eukaryotic deoxyhypusine synthases. Separated by a fairly deep branch, although still strongly related, is a small cluster of proteins from Methanobacterium thermoautotrophicum and Archeoglobus fulgidus, the latter of which has two.
ReferencesSE TIGR DR HAMAP; MF_00153; 15 of 27