HMM Summary Page: TIGR00318

Functionputative adenylyl cyclase CyaB
Gene SymbolcyaB
Trusted Cutoff57.95
Domain Trusted Cutoff57.95
Noise Cutoff31.40
Domain Noise Cutoff31.40
Isology Typehypoth_equivalog
HMM Length174
Mainrole CategoryRegulatory functions
Subrole CategorySmall molecule interactions
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe protein CyaB from Aeromonas hydrophila is a second adenylyl cyclase from that species, as demonstrated by complementation in E. coli and by assay of the enzymatic properties of purified recombinant protein. It has no detectable homology to any other protein of known function, and has several unusual properties, including an optimal temperature of 65 degrees and an optimal pH of 9.5. A cluster of uncharaterized archaeal homologs may be orthologous and serve (under certain circumstances) to produce the regulatory metabolite cyclic AMP (cAMP).
ReferencesA2 hmmalign SE TIGR GA hmmls AL clustalw, belvu BD 0372