HMM Summary Page: TIGR00317

Functioncobalamin 5'-phosphate synthase
Gene SymbolcobS
Trusted Cutoff110.00
Domain Trusted Cutoff110.00
Noise Cutoff87.10
Domain Noise Cutoff87.10
Isology Typeequivalog
EC Number2.7.8.26
HMM Length241
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0008818: cobalamin 5'-phosphate synthase activity molecular_function
GO:0009236: cobalamin biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentcobS is involved with cobalamin biosynthesis in part III of colbalmin biosynthesis. The enzyme catyalzes the reactions adenosylcobinamide-GDP + alpha-ribazole-5'-P = adenosylcobalamin-5'-phosphate + GMP and adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP. The protein product is associated with a large complex of proteins and is induced by cobinamide.
ReferencesDR ECOCYC; EG12150; cobS; DR SWISSPROT; Q05602; RM 93273696 RT Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_00719; 118 of 150
Genome PropertyGenProp0269: coenzyme B12 biosynthesis from cob(II)yrinate diamide (HMM)