HMM Summary Page: TIGR00316

FunctionCO dehydrogenase/CO-methylating acetyl-CoA synthase complex, beta subunit
Gene SymbolcdhC
Trusted Cutoff355.95
Domain Trusted Cutoff355.95
Noise Cutoff355.55
Domain Noise Cutoff355.55
Isology Typeequivalog
EC Number1.2.99.2
HMM Length460
Mainrole CategoryEnergy metabolism
Subrole CategoryChemoautotrophy
Gene Ontology TermGO:0006085: acetyl-CoA biosynthetic process biological_process
GO:0018492: carbon-monoxide dehydrogenase (acceptor) activity molecular_function
GO:0043884: CO-methylating acetyl-CoA synthase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentNomenclature follows the description for Methanosarcina thermophila. The CO-methylating acetyl-CoA synthase is considered the defining enzyme of the Wood-Ljungdahl pathway, used for acetate catabolism by sulfate reducing bacteria but for acetate biosynthesis by acetogenic bacteria such as oorella thermoacetica (f. Clostridium thermoaceticum).
ReferencesRN [1] RM 97113446 RT Analysis of the CO dehydrogenase/acetyl-coenzyme A synthase operon of Methanosarcina thermophila. RA Maupin-Furlow JA, Ferry JG RL J Bacteriol 1996 Dec;178(23):6849-56 SE TIGR GA hmmls AL clustalw DR HAMAP; MF_01138; 10 of 10