HMM Summary Page: TIGR00308

FunctionN2,N2-dimethylguanosine tRNA methyltransferase
Trusted Cutoff280.65
Domain Trusted Cutoff280.65
Noise Cutoff153.90
Domain Noise Cutoff153.90
Isology Typeequivalog
EC Number2.1.1.-
HMM Length375
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0004809: tRNA (guanine-N2-)-methyltransferase activity molecular_function
GO:0030488: tRNA methylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is responsible for two methylations of a characteristic guanine of most tRNA molecules. The activity has been demonstrated for eukaryotic and archaeal proteins, which are active when expressed in E. coli, a species that lacks this enzyme. At least one Eubacterium, Aquifex aeolicus, has an ortholog, as do all completed archaeal genomes.
ReferencesSE TIGR GA hmmls AL clustalw, belvu, seaview DR HAMAP; MF_00290; 21 of 26