HMM Summary Page: TIGR00305

Functionputative toxin-antitoxin system toxin component, PIN family
Trusted Cutoff29.15
Domain Trusted Cutoff29.15
Noise Cutoff28.85
Domain Noise Cutoff28.85
Isology Typeequivalog
HMM Length115
Mainrole CategoryCellular processes
Subrole CategoryOther
Gene Ontology TermGO:0004521: endoribonuclease activity molecular_function
GO:0005515: protein binding molecular_function
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis uncharacterized protein family, part of the PIN domain superfamily, is restricted to bacteria and archaea. A comprehensive in silico study of toxin-antitoxin systems by Makarova, et al. (2009) finds evidence this family represents the toxin-like component of one class of type 2 toxin-antitoxin systems.
ReferencesDR PFAM; PF01850; PIN domain RN [1] RM PMID:19493340 RT Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. RA Makarova KS, Wolf YI, Koonin EV RL Biol Direct. 2009 Jun 3;4:19.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)