HMM Summary Page: TIGR00298

Function2-phosphosulfolactate phosphatase
Gene SymbolcomB
Trusted Cutoff175.05
Domain Trusted Cutoff175.05
Noise Cutoff119.70
Domain Noise Cutoff119.70
Isology Typeequivalog
EC Number3.1.3.71
HMM Length216
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0019295: coenzyme M biosynthetic process biological_process
GO:0050532: 2-phosphosulfolactate phosphatase activity molecular_function
AuthorHaft DH, Dodson RJ
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
Comment2-phosphosulfolactate phosphatase catalyzes the sulfonation of phosphoenolpyruvate to form 2-phospho-3-sulfolactate, the second step in coenzyme M biosynthesis. Coenzyme M is the terminal methyl carrier in methanogenesis.
References[1] RM 11589710 RT Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. A member of a new class of Mg(2+)-dependent acid phosphatases. RL Eur J Biochem. 2001 Oct;268(19):5176-88. RA Graham DE, Graupner M, Xu H, White RH. SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_00490; 27 of 46
Genome PropertyGenProp0892: sulfopyruvate biosynthesis from phoshoenolpyruvate (HMM)