HMM Summary Page: TIGR00294

FunctionGTP cyclohydrolase
Trusted Cutoff100.35
Domain Trusted Cutoff100.35
Noise Cutoff96.10
Domain Noise Cutoff96.10
Isology Typehypoth_equivalog
EC Number3.5.4.-
HMM Length308
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedAug 12 2012 8:47PM
CommentThis family includes type I GTP cyclohydrolases involved in methanopterin in archaea (MptA) and de novo tetrahydrofolate biosynthesis in bacteria (FolE2).
ReferencesRN [1] RM PMID:17497938 RT Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii. RA Grochowski LL, Xu H, Leung K, White RH RL Biochemistry. 2007 Jun 5;46(22):6658-67. RN [2] RM PMID:17032654 RT Discovery of a new prokaryotic type I GTP cyclohydrolase family. RA El Yacoubi B, Bonnett S, Anderson JN, Swairjo MA, Iwata-Reuyl D, de Crecy-Lagard V RL J Biol Chem. 2006 Dec 8;281(49):37586-93. DR HAMAP; MF_01527; 85 of 167