HMM Summary Page: TIGR00291

FunctionrRNA metabolism protein, SBDS family
Trusted Cutoff126.55
Domain Trusted Cutoff126.55
Noise Cutoff104.45
Domain Noise Cutoff104.45
Isology Typeequivalog
HMM Length231
Mainrole CategoryProtein synthesis
Subrole CategoryOther
Gene Ontology TermGO:0003723: RNA binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family, possibly universal in both archaea and eukaryotes, appears to be involved in (ribosomal) RNA metabolism. Mutations in the human ortholog are associated with Shwachman-Bodian-Diamond syndrome.
ReferencesRN [1] RM PMID:15701634 RT The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. RA Savchenko A, Krogan N, Cort JR, Evdokimova E, Lew JM, Yee AA, Sanchez-Pulido L, Andrade MA, Bochkarev A, Watson JD, Kennedy MA, Greenblatt J, Hughes T, Arrowsmith CH, Rommens JM, Edwards AM RL J Biol Chem. 2005 May 13;280(19):19213-20. Epub 2005 Feb 8. DR PROSITE; PS01267;
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)