HMM Summary Page: TIGR00272

Functiondiphthamide biosynthesis protein 2
Trusted Cutoff184.05
Domain Trusted Cutoff184.05
Noise Cutoff146.75
Domain Noise Cutoff146.75
Isology Typeequivalog
HMM Length497
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0017183: peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process
AuthorHaft DH
Entry DateDec 8 1999 11:17AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein has been shown in Saccharomyces cerevisiae to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide. This modified site can then become the target for ADP-ribosylation by diphtheria toxin.
ReferencesA2 hmmalign GA hmmsearch SE TIGR