HMM Summary Page: TIGR00264

Functionalpha-NAC homolog
Trusted Cutoff98.75
Domain Trusted Cutoff98.75
Noise Cutoff62.95
Domain Noise Cutoff62.95
Isology Typehypoth_equivalog
HMM Length116
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00814; 21 of 25