HMM Summary Page: TIGR00263

Functiontryptophan synthase, beta subunit
Gene SymboltrpB
Trusted Cutoff392.45
Domain Trusted Cutoff392.45
Noise Cutoff220.75
Domain Noise Cutoff220.75
Isology Typeequivalog
EC Number4.2.1.20
HMM Length385
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0000162: tryptophan biosynthetic process biological_process
GO:0004834: tryptophan synthase activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentTryptophan synthase catalyzes the last step in the biosynthesis of tryptophan. the beta chain contains the functional domain for or the synthesis of tryptophan from indole and serine. The enzyme requires pyridoxal-phosphate as a cofactor. The pyridoxal-P attachment site is contained within the conserved region [LIVM]-x-H-x-G-[STA]-H-K-x-N] [K is the pyridoxal-P attachment site] which is present between residues 90-100 of the model.
ReferencesDR Swissprot; P00932; DR ECOCYC; EG11025; DR PROSITE; PS00168; SE TIGR GA hmmls DR HAMAP; MF_00133; 288 of 315
Genome PropertyGenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)