HMM Summary Page: TIGR00262

Functiontryptophan synthase, alpha subunit
Gene SymboltrpA
Trusted Cutoff102.35
Domain Trusted Cutoff102.35
Noise Cutoff100.35
Domain Noise Cutoff100.35
Isology Typeequivalog
EC Number4.2.1.20
HMM Length256
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0000162: tryptophan biosynthetic process biological_process
GO:0004834: tryptophan synthase activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentTryptophan synthase catalyzes the last step in the biosynthesis of tryptophan. The alpha chain is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. In bacteria and plants each domain is found on a separate subunit (alpha and beta chains), while in fungi the two domains are fused together on a single multifunctional protein. The signature pattern for trpA contains three conserved acidic residues. [LIVM]-E-[LIVM]-G-x(2)-[FYC]-[ST]-[DE]-[PA]-[LIVMY]-[AGLI]-[DE]-G and this is located between residues 43-58 of the model. The Sulfolobus solfataricus trpA is known to be quite divergent from other known trpA sequences.
ReferencesDR ECOCYC; EG11024; trpA DR PFAM; PF00290; trp_syntA DR PROSITE; PDOC00151; Tryptophan synthase alpha chain signature SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_00131; 381 of 384
Genome PropertyGenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)