| Accession | TIGR00260 |
| Name | thrC |
| Function | threonine synthase |
| Gene Symbol | thrC |
| Trusted Cutoff | 167.10 |
| Domain Trusted Cutoff | 167.10 |
| Noise Cutoff | 108.00 |
| Domain Noise Cutoff | 108.00 |
| Isology Type | equivalog |
| EC Number | 4.2.3.1 |
| HMM Length | 340 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aspartate family |
| Gene Ontology Term | GO:0004795: threonine synthase activity molecular_function |
| | GO:0009088: threonine biosynthetic process biological_process |
| Author | Loftus BJ |
| Entry Date | Apr 20 1999 2:10PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. |
| References | A2 hmmalign
DR ECOCYC; EG11000; thrC
DR PROSITE; PDOC00149; Serine/threonine dehydratases pyridoxal-phosphate attachment site
RM 87080286
SE TIGR
GA hmmls
AL clustalw, belvu
BD 0389 |
| Genome Property | GenProp0159: threonine biosynthesis from aspartate semialdehyde (HMM) |
