HMM Summary Page: TIGR00260

Functionthreonine synthase
Gene SymbolthrC
Trusted Cutoff167.10
Domain Trusted Cutoff167.10
Noise Cutoff108.00
Domain Noise Cutoff108.00
Isology Typeequivalog
EC Number4.2.3.1
HMM Length340
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004795: threonine synthase activity molecular_function
GO:0009088: threonine biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentInvolved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model.
ReferencesA2 hmmalign DR ECOCYC; EG11000; thrC DR PROSITE; PDOC00149; Serine/threonine dehydratases pyridoxal-phosphate attachment site RM 87080286 SE TIGR GA hmmls AL clustalw, belvu BD 0389
Genome PropertyGenProp0159: threonine biosynthesis from aspartate semialdehyde (HMM)