HMM Summary Page: TIGR00257

Functionuncharacterized protein, YigZ family
Trusted Cutoff167.95
Domain Trusted Cutoff167.95
Noise Cutoff117.35
Domain Noise Cutoff117.35
Isology Typehypoth_equivalog
HMM Length205
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis uncharacterized protein family includes YigZ, which has been crystallized, from E. coli. YigZ is homologous to the protein product of the mouse IMPACT gene. Crystallography shows a two-domain stucture, and the C-terminal domain is suggested to bind nucleic acids. The function is unknown. Note that the ortholog from E. coli was shown fused to the pepQ gene in GenBank entry X54687. This caused occasional misidentification of this protein as pepQ; this family is found in a number of species that lack pepQ.
ReferencesRN [1] RM PMID:15103642 RT Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold. RA Park F, Gajiwala K, Eroshkina G, Furlong E, He D, Batiyenko Y, Romero R, Christopher J, Badger J, Hendle J, Lin J, Peat T, Buchanan S RL Proteins. 2004 May 15;55(3):775-7.