HMM Summary Page: TIGR00256

FunctionD-tyrosyl-tRNA(Tyr) deacylase
Gene Symboldtd
Trusted Cutoff101.50
Domain Trusted Cutoff101.50
Noise Cutoff57.15
Domain Noise Cutoff57.15
Isology Typeequivalog
EC Number3.6.1.-
HMM Length146
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004045: aminoacyl-tRNA hydrolase activity molecular_function
GO:0008152: metabolic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis homodimeric enzyme appears able to cleave any D-amino acid (and glycine, which does not have distinct D/L forms) from charged tRNA. The name reflects characterization with respect to D-Tyr on tRNA(Tyr) as established in the literature, but substrate specificity seems much broader.
ReferencesSE TIGR RM 11568181 RT Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases. RA Ferri-Fioni ML, Schmitt E, Soutourina J, Plateau P, Mechulam Y, Blanquet S. RL J Biol Chem 2001 Dec 14;276(50):47285-90 DR HAMAP; MF_00518; 332 of 336