HMM Summary Page: TIGR00254

Functiondiguanylate cyclase (GGDEF) domain
Trusted Cutoff37.40
Domain Trusted Cutoff37.40
Noise Cutoff33.30
Domain Noise Cutoff33.30
Isology Typedomain
HMM Length168
Mainrole CategoryRegulatory functions
Subrole CategorySmall molecule interactions
Gene Ontology TermGO:0009966: regulation of signal transduction biological_process
GO:0009975: cyclase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity [1][3]. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus[2], and FixL, a heme-containing oxygen sensor protein.
ReferencesDR PFAM; PF00990; GGDEF RN [1] RM 11682196 RT Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity. RL FEMS Microbiol Lett. 2001 Oct 16;204(1):163-7. RA Ausmees N, Mayer R, Weinhouse H, Volman G, Amikam D, Benziman M, Lindberg M. RN [2] RM 96042099 RT Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. RL J Bacteriol 1995 Nov;177(21):6223-9 RA Hecht GB, Newton A RN [3] RM 15306016 RT GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. RL Mol Microbiol. 2004 Aug;53(4):1123-34 RA Simm R, Morr M, Kader A, Nimtz M, Romling U RN [4] RM 15569936 RT Structural basis of activity and allosteric control of diguanylate cyclase. RA Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer T. RL Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17084-9