HMM Summary Page: TIGR00250

Functionputative transcription antitermination factor YqgF
Trusted Cutoff43.25
Domain Trusted Cutoff43.25
Noise Cutoff38.45
Domain Noise Cutoff38.45
Isology Typehypoth_equivalog
HMM Length130
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005737: cytoplasm cellular_component
GO:0008150: biological_process biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 27 2014 12:50PM
CommentThis protein family, which exhibits an RNAse H fold in crystal structure, has been proposed as a putative Holliday junction resolvase, an alternate to RuvC.
ReferencesRN [1] RM PMID:22353788 RT Mutations in the essential Escherichia coli gene, yqgF, and their effects on transcription. RA Iwamoto A, Osawa A, Kawai M, Honda H, Yoshida S, Furuya N, Kato J RL J Mol Microbiol Biotechnol. 2012;22(1):17-23. doi: 10.1159/000336517. RN [2] RM PMID:14512736 RT Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold. RA Liu D, Wang YS, Wyss DF RL J Biomol NMR. 2003 Dec;27(4):389-92. RN [3] RM PMID:10982859 RT SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. RA Aravind L, Makarova KS, Koonin EV RL Nucleic Acids Res. 2000 Sep 15;28(18):3417-32. SE TIGR DR HAMAP; MF_00651; 434 of 441