HMM Summary Page: TIGR00246

FunctionrRNA large subunit m3Psi methyltransferase RlmH
Gene SymbolrlmH
Trusted Cutoff149.70
Domain Trusted Cutoff149.70
Noise Cutoff49.10
Domain Noise Cutoff49.10
Isology Typeequivalog
EC Number2.1.1.177
HMM Length155
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0070037: rRNA (pseudouridine) methyltransferase activity molecular_function
GO:0070475: rRNA base methylation biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, in the SPOUT methyltransferase family, previously designated YbeA in E. coli, was shown to be responsible for a further modification, a methylation, to a pseudouridine base in ribosomal large subunit RNA.
ReferencesRN [1] RM PMID:18755835 RT YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RA Purta E, Kaminska KH, Kasprzak JM, Bujnicki JM, Douthwaite S RL RNA. 2008 Oct;14(10):2234-44. Epub 2008 Aug 28. DR ECOCYC; EG11254; ybeA SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00658; 247 of 402