HMM Summary Page: TIGR00244

Functiontranscriptional regulator NrdR
Gene SymbolnrdR
Trusted Cutoff124.65
Domain Trusted Cutoff124.65
Noise Cutoff86.70
Domain Noise Cutoff86.70
Isology Typeequivalog
HMM Length147
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0030528: transcription regulator activity molecular_function
GO:0045449: regulation of transcription biological_process
AuthorHaft DH, Loftus BJ
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this almost entirely bacterial family contain an ATP cone domain (PFAM:PF03477). There is never more than one member per genome. Common gene symbols given include nrdR, ybaD, ribX and ytcG. The member from Streptomyces coelicolor is found upstream in the operon of the class II oxygen-independent ribonucleotide reductase gene nrdJ and was shown to repress nrdJ expression. Many members of this family are found near genes for riboflavin biosynthesis in Gram-negative bacteria, suggesting a role in that pathway. However, a phylogenetic profiling study associates members of this family with the presence of a palindromic signal with consensus acaCwAtATaTwGtgt, termed the NrdR-box, an upstream element for most operons for ribonucleotide reductase of all three classes in bacterial genomes.
ReferencesDR PFAM; PF03477; ATP-cone; ATP cone domain SE TIGR RN [1] RM 15522084 RT Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation. RA Borovok I, Gorovitz B, Yanku M, Schreiber R, Gust B, Chater K, Aharonowitz Y, Cohen G. RL Mol Microbiol. 2004 Nov;54(4):1022-35. RN [2] RM 15949864 RT Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling. RA Rodionov DA, Gelfand MS. RL Trends Genet. 2005 Jul;21(7):385-9. RN [3] RM PMID: 16950922 RT The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons. RA Grinberg I, Shteinberg T, Gorovitz B, Aharonowitz Y, Cohen G, Borovok I RL J Bacteriol. 2006 Nov;188(21):7635-44. Epub 2006 Sep 1. DR HAMAP; MF_00440; 427 of 432
Genome PropertyGenProp0287: ribonucleotide reduction (HMM)