HMM Summary Page: TIGR00243

Function1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene Symboldxr
Trusted Cutoff315.70
Domain Trusted Cutoff315.70
Noise Cutoff224.55
Domain Noise Cutoff224.55
Isology Typeequivalog
EC Number1.1.1.267
HMM Length389
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process
GO:0030604: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity molecular_function
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 14 2011 3:27PM
Comment1-deoxy-D-xylulose 5-phosphate is converted to 2-C-methyl-D-erythritol 4-phosphate in the presence of NADPH. It is involved in the synthesis of isopentenyl diphosphate (IPP), a basic building block in isoprenoid, thiamin, and pyridoxal biosynthesis.
ReferencesRL Proc Natl Acad Sci U S A 1998 Aug 18;95(17):9879-84 SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00183; 297 of 301
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)