HMM Summary Page: TIGR00242

Functiondivision/cell wall cluster transcriptional repressor MraZ
Gene SymbolmraZ
Trusted Cutoff98.35
Domain Trusted Cutoff98.35
Noise Cutoff46.10
Domain Noise Cutoff46.10
Isology Typeequivalog
HMM Length144
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedJul 24 2014 1:30PM
CommentMembers of this family contain two tandem copies of a domain described by Pfam HMM PF02381. This protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc. Recent work shows MraW in E. coli binds an upstream region with three tandem GTGGG repeats separated by 5bp spacers. We find similar sites in other species.
ReferencesDR PFAM; PF02381 RN [1] RM PMID:24659771 RT The highly conserved MraZ protein is a transcriptional regulator in Escherichia coli. RA Eraso JM, Markillie LM, Mitchell HD, Taylor RC, Orr G, Margolin W RL J Bacteriol. 2014 Jun;196(11):2053-66. doi: 10.1128/JB.01370-13. RN [2] RM 10876091 RT Organization and transcription of the division cell wall (dcw) cluster in Neisseria gonorrhoeae. RA Francis F, Ramirez-Arcos S, Salimnia H, Victor C, Dillon JR. RL Gene. 2000 Jun 27;251(2):141-51. DR HAMAP; MF_01008; 260 of 314