Accession | TIGR00238 |
Name | TIGR00238 |
Function | KamA family protein |
Trusted Cutoff | 199.20 |
Domain Trusted Cutoff | 199.20 |
Noise Cutoff | 115.45 |
Domain Noise Cutoff | 115.45 |
Isology Type | subfamily |
HMM Length | 331 |
Mainrole Category | Energy metabolism |
Subrole Category | Electron transport |
Gene Ontology Term | GO:0009055: electron carrier activity molecular_function |
| GO:0055114: oxidation-reduction process biological_process |
Author | Haft DH |
Entry Date | Apr 20 1999 2:05PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents essentially the whole of E. coli YjeK and of some of its apparent orthologs. YodO in Bacillus subtilis, a family member which is longer protein by an additional 100 residues, is characterized as a lysine 2,3-aminomutase with iron, sulphide and pyridoxal 5'-phosphate groups. The homolog MJ0634 from M. jannaschii is preceded by nearly 200 C-terminal residues. This family shows similarity to molybdenum cofactor biosynthesis protein MoaA and related proteins.
Note that the E. coli homolog was expressed in E. coli and purified and found not to display display lysine 2,3-aminomutase activity. Active site residues are found in 100 residue extension in B. subtilis. Name changed to KamA family protein. |
References | SE TIGR
RM 10839984
RT A novel lysine 2,3-aminomutase encoded by the yodO gene of bacillus subtilis: characterization and the observation of organic radical intermediates.
RA Chen D, Ruzicka FJ, Frey PA.
RL Biochem J. 2000 Jun 15;348 Pt 3:539-49 |