HMM Summary Page: TIGR00238

FunctionKamA family protein
Trusted Cutoff199.20
Domain Trusted Cutoff199.20
Noise Cutoff115.45
Domain Noise Cutoff115.45
Isology Typesubfamily
HMM Length331
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0009055: electron carrier activity molecular_function
GO:0055114: oxidation-reduction process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents essentially the whole of E. coli YjeK and of some of its apparent orthologs. YodO in Bacillus subtilis, a family member which is longer protein by an additional 100 residues, is characterized as a lysine 2,3-aminomutase with iron, sulphide and pyridoxal 5'-phosphate groups. The homolog MJ0634 from M. jannaschii is preceded by nearly 200 C-terminal residues. This family shows similarity to molybdenum cofactor biosynthesis protein MoaA and related proteins. Note that the E. coli homolog was expressed in E. coli and purified and found not to display display lysine 2,3-aminomutase activity. Active site residues are found in 100 residue extension in B. subtilis. Name changed to KamA family protein.
ReferencesSE TIGR RM 10839984 RT A novel lysine 2,3-aminomutase encoded by the yodO gene of bacillus subtilis: characterization and the observation of organic radical intermediates. RA Chen D, Ruzicka FJ, Frey PA. RL Biochem J. 2000 Jun 15;348 Pt 3:539-49