HMM Summary Page: TIGR00237

Functionexodeoxyribonuclease VII, large subunit
Gene SymbolxseA
Trusted Cutoff180.00
Domain Trusted Cutoff180.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typeequivalog
EC Number3.1.11.6
HMM Length389
Mainrole CategoryDNA metabolism
Subrole CategoryDegradation of DNA
Gene Ontology TermGO:0006308: DNA catabolic process biological_process
GO:0008855: exodeoxyribonuclease VII activity molecular_function
GO:0009318: exodeoxyribonuclease VII complex cellular_component
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedMay 27 2014 6:46PM
CommentThis family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits.
ReferencesDR ECOCYC; EG11072; RN [1] RM PMID:22718974 RT Delineation of structural domains and identification of functionally important residues in DNA repair enzyme exonuclease VII. RA Poleszak K, Kaminska KH, Dunin-Horkawicz S, Lupas A, Skowronek KJ, Bujnicki JM RL Nucleic Acids Res. 2012 Sep;40(16):8163-74. doi: 10.1093/nar/gks547. RN [2] RM PMID:6284744 RT Subunit structure of Escherichia coli exonuclease VII. RA Vales LD, Rabin BA, Chase JW. RL J Biol Chem. 1982 Aug 10;257(15):8799-805. DR HAMAP; MF_00378; 288 of 293
Genome PropertyGenProp1095: exodeoxyribonuclease VII (HMM)